New study links paracetamol to side effects in digestive tract, heart, kidneys among older adults, ET HealthWorld

New study links paracetamol to side effects in digestive tract, heart, kidneys among older adults, ET HealthWorld

Paracetamol Use Linkedā¤ to Increased Health Risks in ā£Older Adults

paracetamol,a commonly used over-the-counter medication for fever and pain relief,might pose a important risk to older adults. A recent study conducted byā€ researchers at the University ā€of Nottingham has raised concerns about theā£ potential for paracetamol to increase the risk ā€‹of gastrointestinal, heart, ā¤and kidney problems ā€Œin people aged ā£65 and older. While paracetamol is often recommended as the ā€first-lineā€ treatment for osteoarthritis, a chronic condition causing joint pain and stiffness, a growing body of evidenceā€Œ suggests that its benefits may be outweighed by its potential harms, ā¤especially for older individuals who are more susceptible to drug-related complications.

Potentialā€ Side Effectsā¢ of Long-termā€‹ Paracetamol Use

The study, ā€‹publishedā¤ in the ā€journal Arthritis Care and Research, found a concerning link between paracetamol use and an increased riskā€ of several health issues.ā€ Researchers discovered that:
  • Paracetamolā¤ useā¢ wasā£ associated with a 24% higher risk of peptic ulcer bleeding and a 36% increased risk of lower gastrointestinal bleeding.
  • The drug may also elevate the risk of chronic kidney disease by 19%, heart failure by 9%, and hypertension by 7%.
Lead ā€Œresearcherā€ Weiya Zhang ā€of theā€‹ University of Nottingham’s School of Medicineā€‹ highlighted the study’s ā¢findings, stating: “This study shows a significantā€Œ incidence of renal, cardiovascular andā€‹ gastrointestinal side effects in older people, who are prescribed acetaminophen (paracetamol)ā¢ repeatedly in the UK.” Zhang emphasizes the need for further ā£research to confirm these ā¢findings, adding: “Whilst further ā¤research is now needed to ā¤confirm our findings, given its minimalā€‹ pain-relief effect, theā¤ useā¤ of paracetamol as a first line pain ā¤killer for long-term conditions such as osteoarthritisā€‹ in older people needs to be carefully considered.”

Study Methodology ā€‹and Previous Research

The study ā€‹analyzed health records of over 1.8 lakh individuals repeatedly prescribed paracetamol and compared them to a similar-sized group who had not received repeated prescriptions. Data from the Clinical Practice ā€Research Datalink-Gold was used, focusingā€Œ on participants aged 65 and over who had been registered ā¤with ā€Œa ā¢UK general practitioner for at ā¢least a ā¢year between 1998 andā€‹ 2018. Theseā¢ findings ā€build ā€Œupon previous research suggesting ā€that paracetamol might not be as effectiveā€‹ as once thought for pain relief. A 2016 study in The Lancet, which analyzed data from 76 ā¢randomized trialsā€ involving ā£overā¤ 58,000 patients, found that paracetamol did not provide ā£sufficientā¢ pain relief or improve physical function in patients with knee and hip ā€‹osteoarthritis.

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New study links paracetamol to side effects in digestive tract, heart, kidneys among older adults, ET HealthWorld The economic Times Health World website and app provide thorough coverage of health-related news and insights. Available for both Android ā¢and iOS devices, the app allows ā€Œusers to stay informed about the latest medical advancements, health trends, and significantā€Œ health updates. Users can download the app for free from Google ā£Play and the Appā¢ Store. A QR code ā¤is also availableā£ for those who prefer to scan and download the app directly.
## Paracetamol ā€‹and Older Adults: ā£A cause for Concern?



**Q:** ā€ Dr. Smith, a recent study has linked long-term paracetamol use to ā¢increasedā¢ health risks in olderā£ adults. Can you shed some light on thes findings?



**A:** Yes, this study from the University of Nottingham raises some serious concerns. They found that older adults repeatedly prescribed paracetamol were at a higher risk for ā¢gastrointestinal bleeding, cardiovascular ā€‹problems like heart failure and ā€‹hypertension,ā¢ and even chronic kidney disease.



**Q:** These areā¢ serious conditions. What ā¢specifically did the study find regarding the risks?



**A:**Theā£ study, published in ā£Arthritis Careā¢ & Research, showed a 24%ā£ increasedā€ risk of peptic ulcer bleeding and aā€Œ 36% increased risk of lower gastrointestinal bleeding associated withā€‹ paracetamol use. They also found aā¢ 19% higher risk of chronic kidney disease, a 9% higher risk of ā€heart failure, and a 7% higher risk of hypertensionā€‹ in older adults takingā€Œ paracetamol regularly.



**Q:** That’sā¤ alarming. Paracetamol ā£is commonly recommended for pain relief, especially for ā£conditions likeā¤ osteoarthritis. What are the implications of these ā€Œfindings for olderā€‹ adults ā¤with chronic pain?



**A:** This research definitely calls for a reassessment of using paracetamol as a first-line treatment for long-term pain management in older adults.While it might offer some short-term ā£relief, the potential long-termā€Œ side effects, especially considering their age and susceptibility to complications, must beā€ carefully weighed.



**Q:** What alternatives are available for pain management in older adults?



**A:** This is aā£ crucial question that requires a ā€Œconversation with a healthcare professional. There are other pain management options, including different ā¢types of painkillers, physical therapy, and alternative therapies like ā¢acupuncture. A ā¤personalizedā¢ approach ā€Œtaking into account ā£the individual’sā£ specificā¢ healthā€Œ needs and risk factors is vital.



**Q:**ā€ Thank you, Dr. Smith, for providing insight into this critically important issue. It’s crucial for older adults and their families to be aware of these potential risks and have openā£ discussions withā€Œ their doctors about pain management strategies.


**Q:** Dr.Smith, I understand that paracetamol, a medication commonly used for pain relief, might have potential risks for older adults. Can you elaborate on these risks?



**A:** That’s right. Recent research suggests that long-term use of paracetamol, especially in older adults, could be linked to several health problems.This includes an increased risk of gastrointestinal issues like peptic ulcers and bleeding,as well as a higher chance of developing chronic kidney disease,heart failure,and hypertension.



**Q:** This is concerning. What makes older adults more susceptible to these risks?





**A:** As people age, their bodies process medication differently. Their kidneys and liver may not function as efficiently, which can lead to a buildup of medication in the system. This increased concentration can heighten the risk of side effects.



**Q:** Are there alternative pain management options for older adults?



**A:** Absolutely. It’s critically important to have a conversation with your doctor to explore different approaches. Depending on the type and severity of pain, options like physical therapy, alternative therapies like acupuncture, or different types of painkillers might be suitable.





**Q:** What should older adults do if they are currently taking paracetamol regularly?



**A:** if you’re concerned about your paracetamol use, the best thing to do is speak with your doctor. They can assess your individual situation, taking into account your medical history, pain levels, and other medications you’re taking. They can then reccommend the most appropriate pain management strategy for you. Remember, open interaction with your healthcare provider is key to making informed decisions about your health.

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